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Genome Modified Mice

CRISPR Gene Editing

The Vanderbilt Genome Editing Resource (VGER) delivers a streamlined solution for generating custom genetically modified mouse models using cutting‑edge CRISPR/Cas9 technology. With more than 165 engineered strains (including deletions, point mutations, tags, conditional alleles, and reporters) VGER provides comprehensive support from project consultation and allele design through confirmation of germline transmission. VGER also provides support for manuscripts and grant applications, and can collaborate to test and optimize emerging genome‑editing and transgenic technologies.
Crispr background

CRISPR Gene Editing

For more information on specific model types:

Full service genome editing projects include:

  • Project consultation genome editing projects
  • Mutant allele and transgene design
  • CRISPR reagent sourcing and quality control
  • Embryo microinjection or electroporation
  • Screening of founder mice
  • Breeding of founders to confirm germline transmission
  • Sequencing of N1 heterozygous animals to verify allele fidelity
  • Additional quality control assays on a project-specific basis
  • Assignment of official MGI allele name and number
  • Development of an automated genotyping assay in conjunction with TransnetYX
  • Support for manuscripts and grant applications

We can help you test and optimize other types of genome-editing and transgenic technologies under collaborative agreements.