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Zoom meeting information will be sent to VICB and CBAS members one week prior to a seminar date. If you have any questions or need more information, please contact Tia Patton at:\u00a0tia.repscher@vanderbilt.edu<\/a><\/p>\n Wednesday, January 13 Reference Articles:<\/strong> View Kenneth Dawson’s VICB lecture here<\/a> (VU Net ID\/password required).<\/p>\n Wednesday, January 27 View the Schrodinger presentation here<\/a>\u00a0(VU Net ID\/password required).<\/p>\n Wednesday, February 3 Wednesday, February 10 Reference Articles: View Dustin Maly’s VICB lecture here<\/a> (VU Net ID\/password required).<\/p>\n Wednesday, February 24 Reference Articles:<\/strong> View Lyn Jones’ VICB lecture here<\/a> (VU Net ID\/password required).<\/p>\n Wednesday, March 3 References Articles: Wednesday, March 10 Reference Articles:<\/strong> View Laura Kiessling’s VICB lecture here<\/a> (VU Net ID\/password required).<\/p>\n Wednesday, March 17 Reference Articles:<\/strong> View Jason Crawford\u2019s VICB lecture here<\/a> (VU Net ID\/password required).<\/p>\n Wednesday, March 24 \u00a0VICB’s 500th Speaker!\u00a0<\/span> Reference Articles:<\/strong> View Michael Marletta\u2019s VICB lecture here<\/a> (VU Net ID\/password required).<\/p>\n Wednesday, March 31 \u00a0This seminar is being rescheduled for fall 2021.\u00a0<\/span> Reference Articles: Wednesday, April 7 Reference Article: View David Horne\u2019s VICB lecture here<\/a> (VU Net ID\/password required).<\/p>\n Wednesday, April 14 Reference Articles: View Joseph Loo\u2019s VICB lecture here<\/a> (VU Net ID\/password required).<\/p>\n Wednesday, April 21<\/strong> Wednesday,\u00a0April 28 Reference Articles:<\/strong> Wednesday, September 15\u00a0(In-Person & Zoom)<\/strong> Research Summary Points:<\/strong> View the Zoom video<\/a> of Dr. Sperandio’s presentation.<\/p>\n Wednesday,\u00a0September 22\u00a0(In-Person & Zoom)<\/strong> Research Summary Points:<\/strong> View the Zoom video<\/a> of Dr. Baker’s presentation.<\/p>\n Wednesday,\u00a0September 29 (Zoom Only)<\/strong> Research Summary Points: View the Zoom video<\/a> of Dr. Waring’s presentation.<\/p>\n Wednesday, October 6 (In-Person & Zoom)<\/strong> Research Summary Points: View the Zoom video<\/a> of Dr. Mrksich’s presentation.<\/p>\n Wednesday, October 20<\/strong>\u00a0(In-Person & Zoom)<\/strong> Research Summary Points: View the Zoom video<\/a> of Dr. Johnsons’ presentation.<\/p>\n Wednesday,\u00a0October 27\u00a0(In-Person & Zoom)<\/strong> Research Summary Points:<\/strong> Wednesday, November 3 (Zoom Only)<\/strong> Research Overview:<\/strong> Wednesday,\u00a0November 10\u00a0(In-Person & Zoom)<\/strong> Research Summary Points:<\/strong> View the Zoom video<\/a> of Dr. Dentons’ presentation.<\/p>\n Wednesday,\u00a0November 17\u00a0(In-Person & Zoom)<\/strong> Program:\u00a0<\/b>The goal of pharmaceutical development is to deliver novel therapies that can significantly improve the lives of patients.\u00a0 <\/b>Along the drug development pathway there are multiple opportunities to accelerate the development process through thoughtful design of experiments (DoE) and a clear understanding of the regulatory framework.\u00a0 August Bioservices Scientists will discuss the high level milestones of the pharmaceutical development process, focusing on strategies to optimize discovery and increase speed to clinic of confirmed drug candidates.<\/p>\n View the Zoom video <\/a>of the August Bioservices presentation.<\/p>\n Wednesday, December 1<\/strong>\u00a0(Zoom Only)<\/strong> Research Overview:<\/strong> View the Zoom video<\/a> of the Dr. Amaro’s presentation.<\/p>\n
\n<\/strong>Kenneth Dawson<\/a>\u00a0<\/strong>– UNIVERSITY COLLEGE, DUBLIN
\n“The Profound Role of the Nanoscale in Biology and Medicine; Perspectives on Modern Bionanoscience”<\/em>
\n12:15 P.M. \u2014 1:15 P.M.<\/p>\n
\nMapping protein binding sites on the biomolecular corona of nanoparticles<\/a>
\nClassification and biological identity of complex nano shapes<\/a>
\nInfluence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles<\/a><\/p>\n
\n<\/strong>Schrodinger Demonstration<\/a> with Jenny Chambers
\n<\/strong>Using Molecular Modeling to Advance Chemical Biology Research <\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0Zoom<\/p>\n
\n<\/strong>Robert Spitale<\/a>\u00a0<\/strong>–\u00a0UNIVERSITY OF CALIFORNIA – IRVINE
\nChemical Approaches to Analyzing the Structure of the Transcriptome<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0Zoom<\/p>\n
\nDustin Maly<\/a><\/strong>\u00a0–\u00a0UNIVERSITY OF WASHINGTON
\nAllosteric Modulation of Protein Kinases Through Their ATP-Binding Sites<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0\u00a0Zoom<\/p>\n
\n<\/strong>Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes<\/a>
\nA Combined Approach Reveals a Regulatory Mechanism Coupling Src\u2019s Kinase Activity, Localization, and Phosphotransferase-Independent Functions<\/a>
\nParallel Chemoselective Profiling for Mapping Protein Structure<\/a><\/p>\n
\n<\/strong>Lyn Jones<\/strong><\/a> – DANA FARBER\/HARVARD
\nTarget Identification and Validation Using Chemical Biology<\/em>
\n12:15 P.M. \u2014 1:15 P.M.<\/p>\n
\nApplications of chemogenomic library screening in drug discovery<\/a>
\nRational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes<\/a>
\nTarget validation using chemical probes<\/a><\/p>\n
\n<\/strong>Wonhwa Cho<\/strong><\/a> – UNIVERSITY OF ILLINOIS AT CHICAGO
\nLipids & Cancer: New Pathways & Mechanisms<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0\u00a0Zoom<\/p>\n
\n<\/strong>Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol<\/a>
\nPI 3-Kinase Signaling: AKTing up inside the Cell<\/a><\/p>\n
\n<\/strong>Laura Kiessling<\/a>\u00a0<\/strong>– MIT
\nGlycans in Health and Disease<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0\u00a0Zoom<\/p>\n
\nImaging mycobacterial growth and division with a fluorogenic probe<\/a>
\nChemistry-driven glycoscience<\/a>
\nStereoelectronic Effects Impact Glycan Recognition<\/a><\/p>\n
\nJason Crawford<\/a><\/strong> – YALE UNIVERSITY
\nDecoding metabolism at the host-microbe interface<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0\u00a0Zoom<\/p>\n
\nSulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in <\/a>Escherichia coli
\n<\/em>Characterization of Autoinducer-3 Structure and Biosynthesis in <\/a>E. coli
\n<\/em>Structure elucidation of colibactin and its DNA cross-links<\/a><\/p>\n
\nMichael Marletta<\/a><\/strong> – UNIVERSITY OF CALIFORNIA – BERKELEY
\nNitric Oxide Signaling: From Prokaryotes to Humans<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0\u00a0Zoom<\/p>\n
\nPhysiological activation and deactivation of soluble guanylate cyclase<\/a>
\nStructural Insight into H\u2010NOX Gas Sensing and Cognate Signaling Protein Regulation<\/a>
\nAllosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy<\/a><\/p>\n
\nWendy Gordon<\/a>\u00a0<\/strong>– UNIVERSITY OF MINNESOTA
\nDecoding mechanotransduction mechanisms of cell surface receptors<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0\u00a0Zoom<\/p>\n
\n<\/strong>Enhanced Molecular Tension Sensor Based on Bioluminescence Resonance Energy Transfer (BRET)<\/a>
\nA toolkit for studying cell surface shedding of diverse transmembrane receptors<\/a><\/p>\n
\nDavid Horne<\/a><\/strong> – CITY OF HOPE
\nCD33 CAR T Cell Therapy for (r\/r) Acute Myeloid Leukemia<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0\u00a0Zoom<\/p>\n
\n<\/strong>An introduction to chimeric antigen receptor (CAR) T\u2010cell immunotherapy for human cancer<\/a>
\n<\/strong><\/p>\n
\n<\/strong>Joseph Loo<\/strong><\/a> – UNIVERSITY OF CALIFORNIA-LOS ANGELES
\nMass Spectrometry Au Naturel: A Tool to Impact Brain Health Studies and for Structural Biology<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0\u00a0Zoom<\/p>\n
\n<\/strong>New astroglial injury-defined biomarkers for neurotrauma assessment<\/a>
\nAn integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and<\/a>
\nfunction of macromolecular complexes<\/a>
\nNative Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator<\/a>
\n<\/strong><\/p>\n
\nLaura Dassama<\/strong><\/a> – STANFORD UNIVERSITY
\nChemical biology approaches for treating hematologic disorders<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0\u00a0Zoom<\/p>\n
\nLivia Eberlin<\/a><\/strong> – UNIVERSITY OF TEXAS AT AUSTIN
\nAdvancing Cancer Research and Patient Care with Mass Spectrometry Technologies<\/em>
\n12:15 P.M. \u2014 1:15 P.M. \u00a0\u00a0Zoom<\/p>\n
\nPerformance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer<\/a>
\nPreoperative metabolic classification of thyroid nodules using mass spectrometry imaging of fine-needle aspiration biopsies<\/a>
\nNondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system<\/a><\/p>\n
\nVanessa Sperandio<\/strong> – University of Texas-Southwestern,\u00a0“The Highs and Lows of Enteric Infections”<\/p>\n
\n1) gut-brain axis
\n2) enteric pathogens
\n3) inter-kingdom chemical signaling<\/p>\n
\nPaul Baker<\/strong> – Sciex\u00a0(In-Person & Zoom), “In-Depth Structural Characterization of Lipids by Electron Activated Dissociation: Redefining Global Lipidomics Analysis”<\/p>\n
\n1) \u00a0Most current approaches to lipidomics analysis by
\nmass spectrometry lack structural characterization
\nof individual lipid molecular species. Rather,
\nlipids are typically defined with broad
\nclassifications such as sum composition, which
\nlacks specificity.
\n2) \u00a0Electron Impact Excitation of Ions from Organics
\n(EIEIO) is a novel fragmentation method that
\nenables complete structural elucidation of lipids,
\nincluding the class, fatty acid composition,
\nlocation of fatty acids, and the position and
\nstereochemistry of double bonds in a single
\nexperiment.
\n3) \u00a0Using HPLC ESI MS\/MS with electron activated
\ndissociation makes possible the ability to
\nidentify putative lipid biomarkers of human disease
\nwith structural specificity.<\/p>\n
\nMike Waring<\/strong> – Newcastle University
\n“Approaches to Hit-Finding Using FragLites and Encoded Libraries”<\/p>\n
\n<\/strong>1) \u00a0FragLites are small, halogenated molecules, smaller than traditional fragments, that express single pharmacophores and can be used to identify productive binding interactions in proteins and to assess ligandability.
\n2) \u00a0The utility of FragLites has been demonstrated by mapping interactions with the kinase CDK2 and bromodomains BRD4 and ATAD2.
\nDNA encoded libraries are an incredibly versatile approach to finding hits, but present a challenge for organic synthesis, we have developed highly efficient methods for synthesising DELs using micellar mediated chemistry.
\n3) \u00a0The micellar approach has been used to develop optimised Suzuki and amide couplings to synthesise screening compound on DNA.<\/p>\n
\nMilan Mrksich<\/strong> – Northwestern University
\n“High Throughput Experiments with SAMDI Mass Spectrometry”<\/p>\n
\n<\/strong>1) \u00a0MALDI mass spectrometry is well-suited for analysis of self-assembled monolayers of alkanethiolates on gold
\n2) \u00a0Automation and 1,536 spot plates allow for highthroughput experiments
\n3) \u00a0Important applications in drug discovery, identifying enzyme activities and reaction optimization<\/p>\n
\nCarl Johnson<\/strong> – Vanderbilt University
\n“What Makes Us Tick? Circadian Adventures From Bacteria to Mammals”<\/p>\n
\n<\/strong>1) What are circadian clocks good for?
\n2)\u00a0How does it work in bacteria? Adaptive fitness and mechanism.
\n3) Drugging the mammalian clock\u2013redox redux.<\/p>\n
\nBrian Conlon<\/strong> – University of North Carolina, “Overcoming boundaries to improve antibiotic efficacy against Staphylococcus aureus”<\/p>\n
\n1) Biofilms and intracellular S. aureus represent two major antibiotic tolerant niches
\nduring infection
\n2) Targeting the host cell response can sensitize intracellular S. aureus to antibiotics
\n3) Anti-persister drugs and novel drug delivery<\/p>\n
\nYimon Aye<\/strong> – \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne
\n“Within Our Control? Elucidating On-Target Reactive Metabolite Signaling”
\n12:15 P.M. \u2014 1:15 P.M.<\/p>\n
\nDr. Aye studies proteins\/pathways involved in mammalian genome maintenance and nucleotide signaling, including the mechanisms of anticancer agents in clinical use.<\/p>\n
\nJerod Denton<\/strong> – Vanderbilt University Medical Center
\n“A SWELL time to develop the pharmacology of LRRC8 volume-regulated anion channels”<\/p>\n
\n1)\u00a0Volume-regulated anion channels (VRAC) encoded by LRRC8 genes play important physiological roles and may represent novel drug targets, however the molecular pharmacology of VRAC comprises weak and non-specific inhibitors.
\n2)\u00a0Recent progress toward developing the molecular pharmacology of VRAC sheds new light on the putative regulation of VRAC by leukotriene signaling and oxidative stress.<\/p>\n
\nJenn Adams, Mike Schribner,\u00a0Jeff Elich, &\u00a0Maria McGresham<\/strong>\u00a0– August Bioservices<\/a>, “Accelerating pharmaceutical development through efficient Design of Experiments (DoE)” \u00a0Flyer<\/a><\/p>\n
\nRommie Amaro<\/strong> – University of California-San Diego
\n“Computational Microscopy of SARS-CoV-2”<\/p>\n
\nDr. Amaro’s scientific interests lie at the intersection of computer-aided drug discovery and biophysical simulation. Her scientific vision revolves around expanding the range and complexity of molecular constituents represented in such simulations, the development of novel multi-scale methods for elucidating their time dependent dynamics, and the discovery of novel chemical matter controlling biological function.<\/p>\nArchives<\/strong><\/h2>\n