Research, News & Discoveries

Clostridium difficile (C. difficile) infection is the leading cause of hospital-acquired diarrhea, causing nearly a half million infections in the United States each year. Recurrence after treatment with antibiotics is common and new therapies are needed. Now Heather Kroh, PhD, Ramyavardhanee Chandrasekaran, PhD, Ben Spiller, PhD, Borden Lacy, PhD, and colleagues show that the antibody,… Read More

Researchers at Vanderbilt University have discovered how insulin crosses the capillary endothelium to exit blood vessels and stimulate skeletal muscle cells — a major finding that may lead to new ways to reverse insulin resistance, a hallmark of type 2 diabetes. Their discovery, published earlier this month by the Journal of Clinical Investigation, was… Read More

New Insights into Autism Spectrum Disorder Autism Spectrum Disorder (ASD) comprises a group of developmental disorders characterized by a wide range of symptoms, typically including impaired social interactions and excessive repetitive behaviors. Increasing evidence suggests that the pathophysiology of ASD involves an imbalance between two neuronal pathways, which are… Read More

Multiplexing Natural Products Discovery An organism’s metabolome is the total of all the small molecules that it produces. Efforts to identify bioactive natural products in the metabolomes of microbes, plants, and other organisms are often thwarted by metabolome complexity and the heterogeneous nature of the cell populations to which… Read More

Bingshan Li, associate professor of molecular physiology and biophysics, and David Weaver, associate professor of pharmacology, have been named to the 2018 class of Chancellor Faculty Fellows. The class comprises highly accomplished, recently tenured faculty from all corners of campus. The faculty members will hold the title of Chancellor Faculty Fellow and will be supported by… Read More

Claus Schneider, PhD, and colleagues have now discovered that curcumin is a “pro-drug” that is converted into reactive metabolites with anti-inflammatory activities. The metabolites of curcumin, produced by oxidation reactions, covalently bind to and inhibit proteins in the inflammatory NF-kappa-B signaling pathway. The researchers found that curcumin undergoes oxidation reactions readily in… Read More

Blocking a nerve-cell receptor in part of the brain that coordinates movement could improve the treatment of Parkinson’s disease, dyskinesia and other movement disorders, researchers at Vanderbilt University have reported. Their findings, published recently in the journal Neuron, focus on M4, a subtype of the muscarinic acetylcholine family of nerve cell (neuron) receptors… Read More

Researchers at Vanderbilt University Medical Center (VUMC) have demonstrated for the first time that it is possible to starve a tumor and stop its growth with a newly discovered small compound that blocks uptake of the vital nutrient glutamine. Their findings, reported in this week in Nature Medicine, lay the groundwork for… Read More

Escape of Insulin from Muscle Capillaries Key to the maintenance of homeostasis in a complex, multicellular organism is inter-organ communication by means of molecular signals that are delivered via the circulation. However, to gain access to the target tissue, these molecules must be able to traverse the tightly adherent… Read More

Vanderbilt University has signed separate licensing and research collaboration agreements with Lundbeck, a global pharmaceutical company based in Denmark, to develop a novel approach for treating schizophrenia. “We are excited to have the opportunity to work with our colleagues at Lundbeck to advance this promising new approach for treatment of a devastating… Read More